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兔抗ATXN1多克隆抗体

描述:产品名称:兔抗ATXN1多克隆抗体
英文名:Anti-ATXN1 rabbit polyclonal antibody
别名:ataxin 1; ATX1; SCA1: D6S504E
相关类别:一抗

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  • 厂商性质:经销商
  • 更新时间:2024-08-09
  • 访问量:186
产品介绍/ PRODUCT PRESENTATION

产品名称:兔抗ATXN1多克隆抗体

英文名:Anti-ATXN1 rabbit polyclonal antibody

别名:ataxin 1; ATX1; SCA1: D6S504E

相关类别:一抗

宿主:Rabbit

克隆类型:rabbit polyclonal

储存:冷冻-20℃

反应种属:Human, Mouse, Rat

抗原:ATXN1

概述

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). Alternative splicing results in multiple transcript variants, with one variant encoding multiple distinct proteins, ATXN1 and Alt-ATXN1, due to the use of overlapping alternate reading frames.

兔抗ATXN1多克隆抗体

应用

酶联免疫吸附测定(ELISA),免疫印迹(WB)

属性

保存缓冲液-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件2-8°C
靶点 Uniprot 登记号P54253
靶点基因 ID6310
靶点全称ataxin 1
靶点别名ATX1; SCA1; D6S504E
靶点研究领域Epigenetics and Nuclear Signaling, Neuroscience
亚型Immunogen-specific rabbit IgG





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